Abstract
5-(3’,4’-Dihydroxyphenyl)-γ-valerolactone (DHPV) is a colonic microbial metabolite derived from cacao. In the previous study, we found that cacao powder modulates DNA methylation and inhibits UVB-induced AP-1 activation and MMP-1 expression. To further investigate whether major metabolite of cacao, DHPV, has UV protective effect as cacao, we evaluated the regulatory role of DHPV on DNA methylation in keratinocytes after UVB irradiation. In this study, we found that UVB irradiation altered methylation profiles in HaCaT cells and these changes were ameliorated by DHPV.
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