644 THE IMPACT OF INTRAVESICAL RECURRENCE ON PROGNOSIS AFTER NEPHROURETERECTOMY FOR UPPER URINARY TRACT UROTHELIAL CELL CARCINOMA

Abstract

You have accessJournal of UrologyUrothelial Cancer: Upper Tract Tumors1 Apr 2012644 THE IMPACT OF INTRAVESICAL RECURRENCE ON PROGNOSIS AFTER NEPHROURETERECTOMY FOR UPPER URINARY TRACT UROTHELIAL CELL CARCINOMA Junichi Inokuchi, Kentaro Kuroiwa, Katsunori Tatsugami, Akira Yokomizo, and Seiji Naito Junichi InokuchiJunichi Inokuchi Fukuoka, Japan More articles by this author , Kentaro KuroiwaKentaro Kuroiwa Fukuoka, Japan More articles by this author , Katsunori TatsugamiKatsunori Tatsugami Fukuoka, Japan More articles by this author , Akira YokomizoAkira Yokomizo Fukuoka, Japan More articles by this author , and Seiji NaitoSeiji Naito Fukuoka, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.723AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Bladder tumors have been reported to be found in a range of 15% to 50% after nephroureterectomy (NU) for patients with upper urinary tract urothelial cell carcinoma (UUT-UCC). Although many studies have reported clinicopathological features of UUT-UCC which affect bladder tumor development, these predictive factors are still controversial. Furthermore, the prognostic impact of intravesical recurrence is still contentious. The aim of this study was to identify predictive factors of intravesical recurrence after NU for UUT-UCC and verify prognosis of these patients. METHODS Clinicopathological data from 141 patients who underwent NU for UUT-UCC without distant metastasis between June 1994 and April 2010 in Kyushu University were retrospectively collected. Intravesical recurrence-free survival was analyzed with a log-rank test and a Cox proportional hazard model was used for multivariate analysis. Variables such as prior history of bladder tumor, concurrent bladder tumor, pathological stage, preoperative urine cytology, pathological grade, tumor location, multifocality, presence of CIS and tumor size were assessed. RESULTS The median age and follow-up time after NU were 71 yr (range 32-87) and 35.0 months. For pathological stage, 69 (48.9%) and 72 (51.1%) had non-muscle invasive and muscle invasive diseases, respectively. Of the 141 patients, 63 patients developed intravesical recurrence at a median interval of 8.8 months after NU. Intravesical recurrence-free survival rate at 2 year after NU was 54.0%. 56 (88.9%) of 63 patients had intravesical recurrence within 2 years after NU. Univariate analysis showed concurrent bladder tumor as a predictor for the development of intravesical recurrence. Interestingly patients with intravesical recurrence showed better overall survival rate compared with patients without intravesical recurrence (p=0.023). CONCLUSIONS In this study, patients with intravesical recurrence after NU did not show poor prognosis compared with those without intravesical recurrence, at least. Even though the bladder should be observed in all cases because of high intravesical recurrence rate, intravesical recurrence may not have impact on prognosis. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e262-e263 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Junichi Inokuchi Fukuoka, Japan More articles by this author Kentaro Kuroiwa Fukuoka, Japan More articles by this author Katsunori Tatsugami Fukuoka, Japan More articles by this author Akira Yokomizo Fukuoka, Japan More articles by this author Seiji Naito Fukuoka, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...