Abstract
Six patients with classic Williams syndrome and the behavioural “cocktail party” manner were investigated for glycoprotein bound peptides in 24 h. urines (1). Pathological chromatographic patterns were obtained in all 6. 4 had peptide increases above the normal level. Average for Williams syndrome patients was 20.9 ± 10.5 (n = 6). The normal is 7.9 ± 2.4 μmoles ( n = 7.5 ) hydrolysis released amino acids. The peptide increase may entail a dietary etiology and partly explain behavioural changes (2).1. Reichelt, K.L. et al (1986) Biol Psychiat 21, 1279-12902; Reiss, A. et al (1985) J Pediatrics 106, 247-249
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