639 EVALUATION OF THE ISCHEMIC RENAL INJURY AFTER NEPHRON-SPARING SURGERY USING DYNAMIC RENAL SCINTIGRAPHY AND L-TYPE FATTY ACID BINDING PROTEIN

Abstract

You have accessJournal of UrologyKidney Cancer: Evaluation & Staging (I)1 Apr 2013639 EVALUATION OF THE ISCHEMIC RENAL INJURY AFTER NEPHRON-SPARING SURGERY USING DYNAMIC RENAL SCINTIGRAPHY AND L-TYPE FATTY ACID BINDING PROTEIN Shun Takai, Tokunori Yamamoto, Yoshihisa Matsukawa, and Momokazu Gotoh Shun TakaiShun Takai Nagoya, Japan More articles by this author , Tokunori YamamotoTokunori Yamamoto Nagoya, Japan More articles by this author , Yoshihisa MatsukawaYoshihisa Matsukawa Nagoya, Japan More articles by this author , and Momokazu GotohMomokazu Gotoh Nagoya, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.191AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Renal scintigraphy is an established method to quantitatively assess split renal function. L-type fatty acid binding protein (L-FABP) is a novel urinary biomarker to reflect acute kidney injury and may play a role in predicting the extent of ischemic renal injury following nephron-sparing surgery. We evaluated the ischemic renal injury after nephron-sparing surgery using dynamic renal scintigraphy and urine level of L-FABP in treated kidney. METHODS We performed open and laparoscopic nephron-sparing surgery for 9 patients with small renal mass and inserted ureteral catheter to the treated renal pelvis. Ischemic renal injury of the treated kidney was evaluated by comparing effective renal plasma flow (ERPF) estimated by radionuclide technetium Tc 99m-mercaptoacetyltriglycine (99mTc-MAG-3) renal scintigraphy before and 1 week after the operation. We calculated a previously described variable called baseline weighted differential (b-WD) of ERPF that represent the percentage of loss of kidney function, considering the baseline value with b-WD of ERPF= (1 week Postoperative ERPF- baseline ERPF)/ baseline ERPF. Urine was obtained from the ureteral catheter 4 hours and 24 hours after de-clamping of the renal artery. We defined induction rate of L-FABP by dividing 24 hours level by 4 hours level. The correlation between b-WD of ERPF and induction rate of L-FABP obtained from the ureteral catheter was assessed. RESULTS There was a strong correlation between b-WD of ERPF and the logarithm of induction rate of L-FABP. CONCLUSIONS The results of the present study show that L-FABP is an effective urinary biomarker to predict the extent of ischemic renal injury following nephron-sparing surgery. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e261 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Shun Takai Nagoya, Japan More articles by this author Tokunori Yamamoto Nagoya, Japan More articles by this author Yoshihisa Matsukawa Nagoya, Japan More articles by this author Momokazu Gotoh Nagoya, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...