Abstract
Several studies have indicated that UV-induced DNA photoproducts are removed from epidermal genomic DNA at a slower rate in geriatric skin than in young adult skin. Such a situation may result in a greater need for the translesion synthesis (TLS) pathway of DNA replication, in which specialized DNA polymerases are recruited to sites of DNA damage to replicate across DNA adducts in either an error-free or error-prone manner. Here we show that skin epidermis from geriatric individuals (>65 years of age) exhibits higher levels of mono-ubiquitinated PCNA, a biochemical marker of TLS pathway activation, than the skin of young adults (aged 21-29) following exposure to 700 J/m2 of UVB light.
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