632-P: Flash Glucose Monitoring in Hypoglycemia Monitor in Type 1 Diabetes

Abstract

Aims: Hypoglycemia is an acute complication of patients with type 1 diabetes. This study investigated flash glucose monitoring in hypoglycemia monitor in patients with type 1 diabetes. Methods: A total of 120 patients with type 1 diabetes were recruited and randomly divided to implement FreeStyle LibreTM as flash glucose monitoring group (n=60) and retrospective continuous glucose monitoring system (CGMS) as control group (n=60). Both groups carried out CGMS at least two times a year and filled three questionnaires including Diabetes Monitoring and Treatment Satisfaction Questionnaire (DMTSQ), Diabetes Specific Quality of Life (DQoL) and Chinese Version Hypoglycemia Fear Survey II (CFH II). Clinical Data, CGM metrics and Questionnaire scores were collected at first visit and one year follow up. Results: The result showed that the time below range (TBR) and the glucose coefficient of variation (CV) were significantly higher in flash glucose monitoring group than control group (all P <0.05). TBR was prolonged with the increase of CV (P <0.05) and low blood glucose index (LBGI) (P <0.05) in both two groups. After multiple stepwise linear regression, CV and LBGI were independent risk factors for TBR (Standardized Coefficients β=0.665, β=0.762, respectively, All P<0.001 ). After one year followed up, the scores of DQoL and DMTSQ had no significant difference, but number of hypoglycemia times per month and scores of behavior part of CFH II significantly decreased in flash glucose monitoring group compared with a year ago (all P<0.05). Conclusions: Glucose CV and LBGI were independent risk factors for TBR. And Flash glucose monitoring decreased number of hypoglycemia times per month and fear behavior of hypoglycemia in patients with type 1 diabetes after one year. Disclosure J. Li: None. F. Liu: None. Funding National Key Research and Development Program of China (2017YFC1309601)