Abstract

Abstract Overall Abstract: A fundamental problem in the clinical management of psychosis is that it is difficult to predict outcomes on the basis of the patient’s clinical features. However, data from recent research suggest that a number of different neuroimaging measures and peripheral biomarkers may be used to distinguish patients who present with similar symptoms but have quite distinct clinical outcomes. This approach appears to be particularly promising in relation to two key clinical issues: predicting the onset of illness onset in people at high risk for psychosis and predicting the response to antipsychotic treatment in patients who have developed psychosis. Key findings from studies in these 2 areas of research will be reviewed, and the challenges associated with translating them into clinical practice will be discussed.

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