Abstract

As part of an ongoing longitudinal study of the developmental effects of prenatal methadone exposure, 38 children born to methadone-maintained mothers(M) and 23 matched children but with negative maternal history of drug use(C), received a battery of behavioral assessments at 6 months. No differences were found between M and C subjects on any of the measures. Despite great within-group variance, performance of M subjects was not related to severity of withdrawal, maternal drug dose or polydrug abuse. There were significantly more Bayley scores below 85(predictors of developmental problems) among M vs. C males (x2=5.87,p<.025). This confirms evidence that males are more vulnerable than females to negative environmental factors. It also corroborates animal data linking early methadone exposure to behavioral abnormalities in adult males.

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