629P Patient-reported outcomes in prostate cancer patients receiving PSMA-targeted radionuclide therapy

Abstract

Prostate-specific membrane antigen (PSMA) targeted radionuclide therapy (TRT) is a promising investigational therapy for patients with progressive metastatic castration-resistant prostate cancer. PSMA TRT conjugates a radionuclide emitting alpha radiation (e.g., Actinium-225) or beta radiation (e.g., Lutetium-177) to a small molecule ligand (e.g., PSMA-617) or a monoclonal antibody (e.g., J591) that has affinity for PSMA. Treatment is generally well-tolerated, but adverse events have been reported.