629 IMPACT OF SMOKING STATUS AT DIAGNOSIS ON DISEASE RECURRENCE AND DEATH IN CLEAR CELL RENAL CELL CARCINOMA

Abstract

age 55.4 12.5(SD)) was 246.3 62.5cc. Pre operative eGFR was 84.3 18.9 ml/min/1.73 m2. Over a median follow-up of 36 months, progression to CKD occurred in 42.6% (n 32) patients. Univariable logistic regression analysis showed that renal volume (p 0.01, HR 2.61 95%CI 1.25-5.43), age (p 0.002, HR 1.05 95%CI 1.02-1.09), male gender (p 0.02, HR 2.86 95%CI 1.18-7.14) and pre-operative GFR (p 0.002, HR 0.96 95%CI 0.93-0.98) were associated with postoperative CKD. The ROC area with pre-operative renal volume as a predictor of post-operative CKD was 0.65 (95% CI 0.53 to 0.78). Kaplan Meier analysis showed the median time to CKD after nephrectomy was 22.3 (0-87.6) months for renal volume less than 236cc (log rank p 0.008) but this was not achieved if renal volume is more than 236cc (Figure 1). CONCLUSIONS: Total renal volume measured using ImageJ before radical nephrectomy is associated with development of postoperative CKD. In addition, a total pre-operative renal volume of less than 236 cc can be used as surrogate predictive marker of CKD development after radical nephrectomy.