628: Upper respiratory tract infection during pregnancy: is it associated with adverse perinatal outcome?

Abstract

To determine whether there is an association between upper respiratory tract infection (URTI) requiring hospitalization during pregnancy, and adverse perinatal complications. A retrospective population-based study comparing all singleton pregnancies of patients with and without URTI requiring hospitalization was performed. Multiple logistic regression models were performed to control for confounders. Out of 186, 373 deliveries, 0.13% (n=246) required hospitalization due to URTI during pregnancy. URTI was significantly associated with preterm deliveries (15.9% vs. 7.9%; p<0.001), lower birth weight (3082±624 vs. 3183±546 grams; p<0.001) and higher rate of cesarean deliveries (CD; 20.3% vs. 13.2%; p<0.001) as compared to the comparison group. Even after controlling for possible confounders such as maternal age and parity, using multivariable analyses, the significant association between URTI and preterm delivery (weighted OR=2.2; 95% CI 1.6-3.1; p<0.001), as well as CD (weighted OR=1.5; 95% CI 1.1-2.2; p=0.020) persisted. In contrast, no significant association was documented between URTI and premature rapture of membranes (PROM; 4.9% vs.6.9%; p=0.212), low Apgar scores (<7) at 5 minutes (0.4% vs.0.6%; p=0.761) and perinatal mortality (0-4% vs.1.3 %; p=0.223). Maternal URTI is an independent risk factor for preterm delivery and cesarean delivery.