Abstract
The principal goals in the management of laryngeal cancer are eradication of disease with preservation of function. The optimal treatment should be chosen for each patient. Several points will be emphasized. – The results of conventional radiotherapy in several studies, including results of supraglottis in Institut Curie. The effects of dose-timefractionation on local control. – The results of clinical trials using altered fractionation schedules such as hyperfractionation, accelerated fractionation, treatment with split course, or with concomitant boost-Studies comparing altered schemes to conventional radiotherapy will be reviewed. – The role of chemotherapy as part of combined modality programs and as part of larynx preservation. Results of clinical trials, especially with induction or concomitant chemoradiotherapy will be discussed. – The value of cell kinetics measurements to predict radiosensitivity: labeling index, length of S-phase, potential doubling time and therapeutic implications.
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