Abstract
Objective: To explore the effect of DPN on the gait and balance ability using new a biomechanical monitoring technology. Methods: 176 subjects were divided into 4 groups: Group A (no DPN signs and symptoms, NCV negative, 48), group B (no DPN signs and symptoms, NCV positive, 45), group C (with DPN signs and symptoms, NCV positive, 51) and group D (normal control, 32). The gait, balance, timed up and go test were conducted using the LEGSys and BalanSens system. The difference of biomechanics parameters and their relationship with NCV were analyzed. Results: The stride, stride to height ratio, walking speed, step height and swing (left) of diabetic groups were significantly lower than group D (P < 0.05). The support (left) and double support (right) of diabetic groups were significantly higher than group D (P < 0.05). In eyes-open hard surface stand test, the center of gravity (COG) sway range of side to side and front to back, the ankle sway range of side to side, the COG sway area, the ankle sway area, the COG sway index and the ankle sway index in group B and C were significantly higher than group D (P < 0.05). The stride length and stride to height ratio of group C were lower than group A (P < 0.05). The walking speed, step height and steps per minute of group C were significantly lower than group A and B (P < 0.05). In the eyes open or closed stand balance test, COG sway range of front to back and the sway index of group C were significantly higher than group A (P < 0.05). In the eyes open state, the ankle sway range of front to back, ankle sway index and COG sway velocity of group C were significantly higher than group A (P < 0.05). In the eyes closed state, the hip sway area of group C were higher than group A (P < 0.05). In the mCTSIB test, the COG sway index of group C were significantly higher than group A (P < 0.05). Conclusion: The biomechanics performance in diabetic patients are impaired and further worse by DPN. These defects may achieve an early detection by the new biomechanical monitoring technology. Disclosure W. Deng: None. F. Deng: None. B. Chen: None. Y. Ma: None. X. Jiang: None. D. Armstrong: None. H. Zhou: None. Funding Cultivation Project of Chongqing Youth Medical High-End Reserve Talents (2017HBRC015)
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