Abstract
Skin fibrosis describes an excessive accumulation of connective tissue that can manifest in association with systemic diseases such as scleroderma or locally following chronic tissue injuries resulting in hypertrophic or keloid scars. This fibrotic condition is the most common and visible form of fibrosis, and can cause severe disability, psychological stress and seriously affect morbidity. So far there are no specific treatments to halt or revert fibrosis, emphasising the great and unmet clinical need.
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