Abstract
High mobility group box 1 (HMGB1) is a multifunctional protein and the activity of HMGB1 depends on the redox status; reduced, disulfide, or oxidized form. Besides reduced form exerts a chemoattractive effect and disulfide form act as proinflammatory cytokine, oxidized form has no such effect. We have previously shown that besides disulfide form exacerbate poly(I:C)-induced inflammation, reduced form act as anti-inflammation. We also found that this reduced form might promote wound healing. HMGB1 contains two homologous DNA-binding domains, A- and B-box.
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