Abstract
We studied effects of weaning on Na-K ATPase activity (which establishes the electrochemical gradient for active transport) in rat jejunal homogenates. Normal weaning (Day 21) led to an increase in enzyme activity after 24 hrs (4.26±.18 μmol Pi/mg/hr vs 2.31±.08 μmol Pi/mg/hr in suckling control littermates) (p<.05). Effect of Precocious Weaning (Day 16) (Activity μmol Pi/mg/hr) Effect of Artificially Delayed Weaning (Pups weaned on Day 25) These data indicate: 1) that weaning on Day 21 leads to an increase in Na-K ATPase activity in 24 hrs suggesting activation of preformed enzyme, 2) precocious weaning leads to a gradual increase in enzyme activity suggesting synthesis of new enzyme, and 3) no increase in activity occurs until weaning when weaning is artificially delayed suggesting that Na-K ATPase activity is not induced by endogenous free corticosterone which increases on Days 16-19 of age, which induces other intestinal enzymes.
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