62. RESISTIVE INDEX OF INTERNAL CAROTID ARTERY AND COMMON CAROTID ARTERY IN PATIENTS WITH CEREBRAL SMALL VASCULAR DISEASE

Abstract

Background/Objective: Cerebroarterial pulsatility has been reported to be significantly increased in patients with cerebral small vessel disease (CSVD). Resistive index (RI) is a parameter of pulsatility and describes resistance of the vascular wall. This study aims to describe RI of internal carotid artery (ICA) and common carotid artery (CCA) in CSVD. Methods: This retrospective study evaluated the registry in Neurosonology Lab, between January and June of 2020. Patients were categorized into CSVD and non CSVD diagnosed using brain scan or MRI. CSVD markers such as lacune, microbleeds, perivascular space, and fazekas class are evaluated from MRI. RI of ICA and CCA were measured using Carotid Doppler Ultrasound. Uni- and bivariate analysis were done to evaluate the mean difference. Result: There were 79 subjects with a median age of 60 (49–66) years, comprising 54.4% with CSVD. RI in CSVD was not significantly higher than non CSVD and tended to be lower. RI of patients with CSVD markers such as lacune (ICA 0.69 ± 0.9, CCA 0.77 ± 0.08), microbleeds (ICA 0.68 ± 0.06, CCA 0.72 ± 0.08), perivascular space > 11 (ICA 0.80 ± 0.17, CCA 0.77 ± 0.05) and fazekas ≥2 (ICA 0.69 (0.09), CCA 0.76 (0.08)) tended to be higher than normal population. Conclusions: This study did not find a significantly higher RI in CSVD compared to non-CSVD, but RI of ICA and CCA in CSVD patient has a tendency to be higher than normal population. Further studies with larger sample sizes are needed to determine role of RI.