62. Association Between Influenza Co-infection and Poor Outcomes in Patients Hospitalized with COVID-19

Abstract

BackgroundIn December 2019, a novel coronavirus (COVID‐19) infection emerged in Wuhan, China, establishing itself as a deadly pathogen leading to an ongoing pandemic. The incidence of co-infection of COVID-19 and Influenza has not been widely reported. Both infections have been known to share similar mechanisms of transmission, however currently, there is no evidence regarding the relationship between co-infection between this viruses and worsening outcomes. Once social distancing measures are eased, and daily activities resumed, there is a possibility for a second wave of cases. Given the incidence of influenza is higher during winter, a higher co-infection rate is expected in these months.MethodsIn this study, the aim was to assess the association of influenza co-infection with outcomes in patients diagnosed with COVID-19 in a hospital-based case-control study in Bronx, New York. 19 patients with Influenza co-infection were found in total. 1 patient did not meet inclusion/exclusion criteria. Charts were reviewed from 18 confirmed cases of influenza and COVID-19 patients. Controls were selected from the remaining pool of patients with COVID-19 in the same period. Cases were matched for age, sex and underlying comorbidities (Hypertension, Diabetes Mellitus, liver disease, cardiovascular disease, HIV status, immunocompromised state other than HIV). The measured outcomes were: in-hospital mortality, need for mechanical ventilation, need for vasopressors and need for renal replacement therapy. For each outcome, Chi Square test and Odds ratio were obtained.ResultsAfter statistical analysis, no significative difference was found in the following variables: in-hospital mortality [Odds ratio (OR) 0.769; 95% confidence interval (CI): 0.185–3.191; p value= 0.717], need for mechanical ventilation (OR 1.3; 95% CI: 0.313–5.393; p value= 0.717), need for vasopressors (OR 1.923; 95% CI: 0.383–9.646; p value= 0.423), need for renal replacement therapy (OR 1.0; 95% CI: 0.208–4.814; p value= 1.0).ConclusionThere was no difference in the outcome in COVID-19 patients co-infected with influenza compared to non co-infected patients, however, a larger sample of cases will be needed for further assessment of these outcomes.Disclosures All Authors: No reported disclosures