61P - No change in mean age of diagnosis of breast cancer during 30 years from 1981 to 2011 in the north east of Iran, report of six thousand patients

Abstract

Background: Patterns of breast cancer differ greatly between Asian and Western countries and this study aimed to evaluate the age at the time of diagnosis of breast cancer and it’s probably changes in distribution among patients during 30 years Methods: This cross-sectional study was conducted in Mashhad, Iran from 1981 until 2011. The data of 6274 breast cancer patients were obtained from case records. The duration of study was categorized into three periods: 1981-1990, 1991-2000 and 2001-2011. SPSS software was used for analyses. Results: Mean age at the time of diagnosis was 49.07 ± 12.07 years (male: 56.48 ± 14.14, female: 48.8 ±12.01, p < 0.001). Table presents the mean age of studied patients in each 10 years of study. ANOVA test showed that there was no statistically significant difference (P value= 0.1).Table: 61PDecadesFrequencyMean ageSDYoungestOldest1981-199046747.9712.04318882000-1991177149.0312.33820992001-2011394949.2211.9542098 Open table in a new tab The most frequent histologic type of breast cancer was ductal carcinoma 65.6% others in order were: NOS 19.6%, lobular 3.7%, medullary 2.8%, adenocarcinoma 2.8%, tubular and papillary 0.2%, and 5.1% of other types. Relative frequency of histologic types had significant differences among 3 intervals (p < 0.001), the frequency of adenocarcinoma was decreasing but ductal carcinoma was increasing during 3 decades. Mean age of ductal carcinoma, lobular, medullary and adenocarcinoma was 48.9±11.8, 50.6±12.4, 46.4±11.4, 50.2±11.9, respectively. Mean age had significant differences among these main histologic types (p = 0.002).98% of patients were urban and 2% were rural. The frequency of people living in urban areas increased significantly (p < 00.1) during these 30 years compared with rural areas. Conclusions: Breast cancer occurs in Iranian women at least one decade younger than in women in developed countries. We found no change in mean age of diagnosis of breast cancer during these 30 years from 1981 to 2011. Legal entity responsible for the study: Mashhad University of Medical Sciences Funding: Mashhad University of Medical Sciences Disclosure: All authors have declared no conflicts of interest.