Abstract
Vascular endothelial cells and mesenchymal myofibroblasts play a central role in the pathogenesis of systemic sclerosis (SSc). Remodeling processes of the connective tissue leading to excessive production of collagen and microvasular injuries result in fibrosis of skin and other organs. Activated mesenchymal myofibroblasts mostly contribute to a fibrotic state. Interestingly, vascular endothelial cells can differentiate to myofibroblast-like cells via endothelial to mesenchymal transition (EMT).
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