616 INFLUENCE OF RADICAL PROSTATECTOMY ON THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS AND SPECIFICALLY IN SERUM FREE AND BIOAVAILABLE TESTOSTERONE

Abstract

You have accessJournal of UrologyProstate Cancer: Basic Research1 Apr 2011616 INFLUENCE OF RADICAL PROSTATECTOMY ON THE HYPOTHALAMIC-PITUITARY-GONADAL AXIS AND SPECIFICALLY IN SERUM FREE AND BIOAVAILABLE TESTOSTERONE Juanma Bastarós Hernández, Fernando Agreda, Placer Jose, Planas Jacques, Carles Xavier Raventós, Luis Castro, Gueisy Delgado, and Juan Morote Juanma Bastarós HernándezJuanma Bastarós Hernández Barcelona, Spain More articles by this author , Fernando AgredaFernando Agreda Barcelona, Spain More articles by this author , Placer JosePlacer Jose Barcelona, Spain More articles by this author , Planas JacquesPlanas Jacques Barcelona, Spain More articles by this author , Carles Xavier RaventósCarles Xavier Raventós Barcelona, Spain More articles by this author , Luis CastroLuis Castro Barcelona, Spain More articles by this author , Gueisy DelgadoGueisy Delgado Barcelona, Spain More articles by this author , and Juan MoroteJuan Morote Barcelona, Spain More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1469AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The role played by the prostate gland on the hypothalamic-pituitary-gonadal axis is not well documented and there are conflicting data regarding the behavior of serum testosterone after radical prostatectomy (RP) and its possible influence on libido and erectile dysfunction postoperatively. The aim of this study was to evaluate the influence of PR on the hypothalamic-pituitary-gonadal axis and specifically in serum free and bioavailable testosterone. METHODS We determined the serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin (PRL), total testosterone (TST), free testosterone (TSTl) before and three months after the PR and 60 patients with prostate cancer located (CAP) whose age ranged between 52 and 68 years. TSTbd was also calculated using the formula of Vermeulen from TST concentrations, albumin and SHBG. No patient included in the study had previously undergone pelvic radiation, or androgen suppression or 5ARIs therapy. All measurements were performed in central laboratory automated methods, in fasting and between 8:00 and 10:00 am. Statistical comparisons of means were performed using the Wilcoxon test. RESULTS Mean levels of LH were 3.48 U/l (2.85 to 4.11) before and 4.35 U/l (3.61 to 5.09) after PR (p = 0,001). Mean levels of FSH were 6.92 U/l (5.47 to 8.37) before and 8.32 U/l (6.51 to 10.14) after PR (p = 0.002). The average levels of PRL were 6.22 ng/mL (4.97 to 7.46) before and 7.32 ng/mL (5.81 to 8.84) after PR (0039). TST average levels were 496.75 ng/mL (456.47 to 537.36) before and 447.50 ng/mL (410.97 to 484.03) after PR (p = 0.009). TSTl average levels were 7.78 pg/mL (6.99 to 8.58) before and 7.60 pg/mL (6.69 to 8.50) after PR (p = 0.41). TSTbd average levels were 220.23 U/l (200.86 to 239.59) before and 212.86 U/l (196.32 to 229.4) after PR (p = 0.35). We did not detect an influence of Gleason grade of the tumor in the observed changes. CONCLUSIONS The prostate gland seems to have a feed back effect on the hypothalamic-pituitary-gonadal axis. Serum total testosterone were significantly reduced after the PR. However, the levels of free testosterone and bioavailable testosterone are not affected by the PR. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e248 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Juanma Bastarós Hernández Barcelona, Spain More articles by this author Fernando Agreda Barcelona, Spain More articles by this author Placer Jose Barcelona, Spain More articles by this author Planas Jacques Barcelona, Spain More articles by this author Carles Xavier Raventós Barcelona, Spain More articles by this author Luis Castro Barcelona, Spain More articles by this author Gueisy Delgado Barcelona, Spain More articles by this author Juan Morote Barcelona, Spain More articles by this author Expand All Advertisement Advertisement Loading ...