Abstract
Triazolo[5,1-b]purines are rare structural analogues of natural nucleosides and nucleobases purine series. At the same time, prominent representatives of azolopurines exhibit a broad spectrum of antiviral effect, activity against of rheumatoid arthritis, psoriasis, Alzheimer's, Parkinson's and etc. Despite the practical value azolo[5,1-b]purines extremely sparingly represented in the chemical literature, due to the complexity of their synthesis. We suggest a convenient way to synthesize triazolopurines with aminotriazolo[1,5-a]pyrimidines (2) as available starting compounds obtained in good yield by reduction of nitro derivatives (1).
Highlights
Triazolo[5,1-b]purines are rare structural analogues of natural nucleosides and nucleobases purine series
One of the most widespread way to turn azinons in aminazines is chorine deoxygenization of heterocycles followed by amination of chlorinated derivatives1,2
Spectroscopic data and elemental analysis showed the formation of triazolopurine
Summary
Triazolo[5,1-b]purines are rare structural analogues of natural nucleosides and nucleobases purine series. One of the most widespread way to turn azinons in aminazines is chorine deoxygenization of heterocycles followed by amination of chlorinated derivatives1,2.
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