614-P: Fear of Hypoglycemia, Hypoglycemia Confidence, and Time in Range in Adolescents and Young Adults with Type 1 Diabetes (T1D)

Abstract

Fear of hypoglycemia (FOH) and low hypoglycemia confidence (HC) can lead to hypoglycemia avoidance behaviors which may influence glycemia in people with T1D. Despite links with A1c, there are limited data on the correlation of FOH or HC with time in range (TIR) , which represents a more complete picture of glycemia. We explored FOH and HC in relation to CGM-derived glycemic metrics. Methods: Participants (n=20, M age 16.3 ± 2.5y, 45% female, M A1c 7.3 ± 1.3%, 100% CGM use; 70% pump use) completed questionnaires assessing FOH and HC, and CGM data were collected over the next 12 weeks. Data were analyzed using Pearson correlations. Results: Table 1 presents correlations between FOH, HC and glycemic metrics. FOH in young adults, specifically Worry, was associated with less time below range (<70 mg/dl; r = -0.75, p =.05) . No other statistically significant correlations between FOH, HC and TIR were detected. Conclusion: Young adults’ worries related to FOH correlate with less level 1 hypoglycemia (<70 mg/dL) due to reasons other than hypoglycemia avoidance behaviors, which merits further study. The small sample size limited the power to detect additional significant associations of FOH/HC with TIR, though patterns suggest several possible links. Advanced technology such as closed-loop systems coupled with psychosocial interventions aimed at reducing FOH and improving HC may help optimize TIR. Disclosure S.Menon: None. D.Desalvo: Consultant; Dexcom, Inc., Insulet Corporation, Research Support; Insulet Corporation. M.Erraguntla: None. K.Pamidimukkala: None. S.Mckay: None. C.Villegas: None. M.E.Hilliard: None. Funding Food and Drug Administration (FDA)