Abstract

Early after skin wounds, innate immune cells, including natural killer (NK) cells, infiltrate the wound bed within the first 24 hours. The application of widely used calcium alginate dressings facilitates cutaneous healing by releasing Ca2+ ions into the exudate and locally enriching its level. Since Ca2+ ions have been identified as one of the main activators of NK functions, the effects of two alginate dressings, Algosteril® (Algo, pure Ca2+ alginate) and Biatain® Alginate (BIA, Ca2+ alginate with CMC), and CaCl2 solution were compared on NK cell cytotoxicity by analyzing K562 lysis and CD107a expression as well as on their IFN-γ and TNF-α production.

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