Abstract
Background: Ultraviolet B irradiation (UVB) contributes to skin inflammation. As UVB mostly affects the epidermis, the crosstalk between epidermis and dermis in the response to UVB needs investigation. Extracellular vesicles (EVs), lipid bilayer membrane vesicles secreted by cells, can carry lipids, proteins and nucleic acids to mediate signal transduction. Stimulator of interferon genes (STING) and inflammasome activation-mediated pyroptosis play critical roles in immunity and inflammation. EVs derived from UVB-irradiated keratinocytes might trigger STING and inflammasome-mediated proinflammatory responses.
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