613 Evaluating the role of copper ions in the various phases of burn and wound healing by using an ex vivo human burn model

Abstract

Copper is known for its strong biocidal and anti-inflammatory properties, and as an accelerator of angiogenesis, cell proliferation and secretion of Extra Cellular Matrix (ECM) proteins. It is therefore an excellent candidate in the treatment of wounds. The role of few factors which presumably mediate copper’s ability to promote wound healing processes is already established. However, the molecular mechanism by which copper facilitates healthy wound healing in a way that can explain the connection between the early events in the wound microenvironment with later healing processes such as tissue formation and remodeling is not entirely clear.