610 Skin-sparing Mastectomy and Immediate Breast Reconstruction is a Safe Option in the Management of Early Stage Breast Cancer Patients

Abstract

had ER positive tumors in 76.5% vs. 47.3% in other group, PR positive tumors in 46.8% vs. 52.3% in other, HER 2/neu negative tumors in 76.9% vs. 56.2% in other. Patients with a positive margins at the initial resection showed higher lobular histology rate (15.3% vs. 6.4%), incidence of multiple ipsilateral tumors (23.1% vs. 15.4%), presens of intraductal component (76.9% vs. 65.1%), but these differences between two groups were no statistically significant. 73.1% of all patients were tested for the two common founder mutaions in BRCA1(4153delA and 5382insC). There was 1 BRCA1(5382insC) mutation-positive patient in the other group and no mutation-positive patients in the positive margin group. Mean follow-up time was 19.9(11−37) months, and there were no local recurrences during the follow-up period in the tumor positive margin group. Conclusion: The overall percentage of positive margins in the Pauls Stradins Clinical University Hospital Breast Unit is within the predefined targets. Lobular histology, multiple ipsilateral tumors and presens of intraductal component have shown a tendency of higher risk for inadequate margins of excision.