6-甲氧基-1, 2, 3, 4-四苯基萘及1-(4-甲氧基苯基)-2, 3, 4-三苯基萘之合成與討論

Abstract

Highly substituted naphthalenes have been studied for a long times in organic synthesis chemistry, but the isomers produced in the synthesis process are rarely discussed. Different reaction conditions will result in different product ratio of highly substituted naphthalene isomer: 6-methoxy-1,2,3,4-tetraphenylnaphthalene (26a) and 1-(4-methoxyphenyl)-2,3,4-triphenylnaphthalene (26b). The structure of 1-(4-methoxyphenyl)-2,3,4-triphenylnaphthalene (26b) is rarely discussed and synthesized by one-step procedure, so main purpose we want of this research is to develop a simple synthetic method to get only one isomer(26b). Different reaction condition such as solvent, catalyst, ligand, base and heating time were tested. The best condition is using THF, Pd(OAc)2 5 mol% / PCy3 15 mol%, 0.5eq AgOAc as base individually, but as we gather all the best condition there are not better then we think. In view of this, we will discussed more deeply about raising the ratio of 1-(4-methoxyphenyl)-2,3,4-triphenylnaphthalene(26b)