605 FETO-MATERNAL ABO INCOMPATIBILITY. A DISCRIMINANT ANALYSIS TO PREDICT SERUM BILIRUBIN LEVELS IN THE NEONATAL PERIOD

Abstract

Two series of newborn infants (432 white (W) and 99 Negro (N)) , collected at Yale-New Haven Hospital from 1968 to 1971, were studied. Each series, which included only infants ABO incompatible-Rh compatible, was subdivided into 2 groups according to the maximum serum bilirubin level (SBL<10 mg/dl or > 10 mg/dl)recorded during the neonatal period. A discriminant analysis was performed in males (m) and females (f) separately on the following 8 variables: gestational age, birth weight, birth order, ABO maternal phenotype, type of feto-maternal ABO incompatibility, Coombs test, presence of IB (ABO) and Plfl (placental alkaline phosphatase) factors, dose of pli-plrare factors. The percent of correct classifications was 83% in Wf, 73% in Wm, 77% in Nf and 75% in Nm. By the present method of discrimination an early discharge of more than 50% of ABO incompatible infants with a very low risk of hyperbilirubinemia might be allowed. The analysis showed a remarkable influence of sex and race on the pattern of relationships between the SBL and the set of variables examined.(Supported by NATO Grant 554).