Abstract
Keloids are debilitating pathological scars with distinct physical (hard and dense) and histological (hyalinization) characteristics compared to normal scars. We recently reported proteomic and histological data indicating that keloids uniquely have a cartilage-like ECM protein composition compared to normal scars and normal skin, which may underpin these differences. This study extends our characterisation and mechanistic understanding of the composition and organisation of the keloid ECM. Primary patient-matched fibroblasts isolated from keloid tissue (KDF) and adjacent unaffected skin (NDF) were subjected to various in vitro culturing conditions, followed by transcriptional analysis and imaging.
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