Abstract
We previously identified a strong overexpression of GPRC5A (G Protein-Coupled Receptor Class C Group 5 Member A) in keratinocytes from the skin wound edges in vivo, and in response to stiffness modulations in vitro, concomitantly to the translocation of its C-terminal region into the nucleolus. To better understand the role of this receptor in keratinocyte mechano-sensing, GPRC5A knock-down was performed in N/TERT-1 cells using a short-hairpin RNA approach, and a recombinant polypeptide mimicking the C-terminal region of GPRC5A (GPRC5A-Rec) was tested to rescue cell phenotype.
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