602: Is there an association between family history of diabetes mellitus and cardiovascular morbidity of offspring?

Abstract

Gestational diabetes mellitus (GDM) was previously noted as an independent risk factor for long-term cardiovascular morbidity of parturient and their offspring. The objective of this study was to investigate whether an association exists between family history of diabetes mellitus (DM) in non-diabetic mothers and long-term pediatric cardiovascular morbidity of their offspring. In a population-based cohort study, the incidence of cardiovascular disorders was compared between offspring of non-diabetic mothers with and without a family history of DM. Cardiovascular morbidity was assessed until 18 years of age according to a predefined set of ICD-9 codes associated with hospitalization of offspring. Multiple gestations, mothers with pre-gestational or gestational diabetes, lack of prenatal care, and children with congenital malformations and chromosomal abnormalities were excluded from the study. A Kaplan– Meier survival curve was used to compare cumulative morbidity incidence. A cox proportional hazards model was performed to control for confounders. A total of 208,728 deliveries were included in the study. Of them, 17,040 (8.2%) offspring were born to non-diabetic mothers with a family history of DM. Total cardiovascular morbidity was comparable between the study groups (0.6% vs. 0.7%, p=0.416; Table 2). The Kaplan–Meier survival curve exhibited no difference in the cumulative incidence of total cardiovascular morbidity of the offspring (log-rank test, p=0.271; Figure 1). Likewise, a Cox regression model found that a family history of DM in non-diabetic mothers was not independently associated with long-term cardiovascular morbidity of the offspring after controlling for confounders such as maternal age, birth- weight, caesarian delivery and maternal hypertensive disorders (aHR= 1.13, 95% CI 0.93-1.37, p= 0.220). A family history of DM in non-diabetic parturient does not increase the risk for long-term cardiovascular morbidity of their offspring.View Large Image Figure ViewerDownload Hi-res image Download (PPT)