Abstract
Wound exudates are considered liquid biopsies of wounds and contain the pathogenic drivers of chronicity. The effects of different types of exudates on healthy primary human dermal fibroblasts (HDF) were investigated, demonstrating growth- and matrix-inhibitory as well as pro-inflammatory effects of chronic wound exudates. To identify potential drugs which could reverse these adverse effects, chemical compounds and growth factors were screened in a proliferation assay. Exudates from healing or chronic venous-, arterial-, mixed-, pressure- and diabetic ulcers, as well as surgical wounds were harvested by negative pressure therapy or using nylon-flocked swabs.
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