Abstract
Macrophages are located around hair follicles in normal skin and typically peak in density during the mid-telogen stage of the hair cycle. Hair follicles chemotactically attract macrophages and T cells and are in range to regulate hair follicle stem cells (HFSCs) quiescence, proliferation, and differentiation during physiologic and injured states. The expression of the fractalkine receptor CX3CR1 has been identified as a key regulator of macrophage and T cell migration and function at sites of inflammation.
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