Abstract
Background: Extra-hepatic biliary atresia (EHBA) is a neonatal disease which results in obliteration of the biliary tree. Infection with viruses may be a cause of EHBA. A murine model of biliary atresia has been established in which rhesus rotavirus (RRV) infection of newborn mice leads to an obstructive cholangiopathy. Recently, a rotavirus vaccine has been approved for use in childhood. We determined whether post conception rotavirus vaccination could prevent the murine model of biliary atresia.
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