Abstract
The mechanism of inflamed dermal tissue permebility in filter paper-implanted rats and the inhibitory effect of anti-inflammatory drugs were investigated. In order to elucidate the mechanism, quantitative changes of connective tissue components [acid mucopolysaccharide (AMPS), glycoprotein (GP) and collegen (C)] in inflamed tissues and the effect of anti-inflammatory drugs were tested. 1) When inflamed tissue was divided into skin side upper fiilter paper and the under muscle one, AMPS content in the muscle side and the GP in both tissues increased very rapidly and markedly. Peaks of both component levels were reached at day 5 or 7. Later AMPS level decreased slightly and thereafter remained at a constant level (almost twice the normal level) until day 25. On the other hand, the GP level thereafter followed a slow reduction, which was more pronounced on the skin side than in muscle one, the level on the skin side fallen to the normal level by day 25. C content in the muscle side of filter paper-implanted rats increased progressively until day 25, while the level on the skin side became markedly lower than normal. 2) The effect of anti-inflammatory drugs (acetylsalicylic acid, aminopyrine, phenylbutazone, bucolome, flufenamic acid, benzydamine HCI, indomethacin, prednisolone and dexamethasone) administered orally once a day for 3 days was examined 3 days after implantation. The increase of AMPS content on the muscle side was inhibited significantly by all these drugs. Acetylsacylic acid, phenylbutazone, flufenamic acid indomethacin and prednisolone also inhibited significantly the increase of GP content in both tissues, whereas benzydamine HCl and dexamethasone effected only in the skin side and bucolome only in muscle side. The decrease of C content in skin side was inhibited remarkably by predni-solone, dexamethasone and indomethacin. 3) The inflamed dermal tissue permeability and GP content in the same region, following a similar pattern, changed during an inflammatory process. A correlation was proved between the inhibitory effect of anti-inflammatory drugs on this two parameters.
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