Abstract
The current trends for focusing on biopolymer-based drug delivery systems (DDSs) are primarily attributed to their biodegradability, biocompatibility, and natural abundance. Cyclodextrins (CDs) are among the most useful biopolymers in drug delivery, as they enhance the solubility of poorly water-soluble drugs. CD-based host–guest interactions offer a flexible and powerful platform for the development of versatile nanosystems. This chapter summarizes the sources, properties, modifications, and characterization of various CDs along with their applications in drug delivery in the form of nanoparticles, nanocarriers, nanosponges, and nanoassembly. The modifications of the CDs enhance the stability of host–guest interactions. Furthermore, recent advancements in the field of tailor-made CDs give a promising and intelligent way of designing new DDSs. Thus this chapter also describes the design and applications of various stimuli-responsive nanomaterials for controlled drug delivery to treat different cancer types.
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