6 Oral - STAR0602, a novel TCR agonist antibody, demonstrates potent antitumor activity in refractory solid tumor models through the expansion of a novel, polyclonal effector memory T cell subset

Abstract

Background: Limitations with agents that activate endogenous T cell responses to cancer, particularly in the setting of solid tumors, supports the study of alternative mechanisms. STAR0602 is a bifunctional antibody—fusion molecule that selectively activates and expands a sub—set of human aβ T cells expressing the germline—encoded variable b6 and b10 regions of the T cell receptor (TCR). STAR0602 simultaneously engages a novel, direct TCR activation with a cis-binding cytokine co-stimulation through the fusion of IL-2 to an inactivated Fc domain bearing an anti-TCR Vb6/Vb10 Fab.