6] Modifications of older model nuclear magnetic resonance console for collection of multinuclear, multidimensional spectral data

Abstract

Pursuant to the original description by Kay, Ikura, Tschudin, and Bax, a growing variety of double- and triple-resonance, three-dimensional (3D) and four-dimensional (4D) nuclear magnetic resonance (NMR) experiments have been developed. Although fully equipped commercial NMR spectrometer consoles produced after 1990 have been capable of performing these demanding experiments, earlier consoles lack the necessary decoupling capabilities and requisite number of transmitter channels. Thus, although the original two-dimensional (2D) triple-resonance experiments have been able to be carried out some of with a standard 1985 vintage Bruker Instruments AM-400 NMR spectrometer and BSV-3 X-nucleus decoupler, it was needed to make extensive modifications in order to perform multinuclear 3D and 4D experiments. Kay et al. described the adaptation of a Bruker AM console for early 3D and 4D triple-resonance experiments. With more extensive modifications, most of the current multinuclear 3D and 4D experiments have been able to be performed with older model Bruker Instruments AM-500 and AM-600 consoles and BSV-3 X-nucleus decouplers.