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Abstract
As part of a study of diamidines which has extended over many years, we have recently screened for trypanocidal and babesicidal activity a number of compounds in which one of the amidine groups has been replaced by a cyclic amidine group. One of the most active of these is 6-(m-amidinophenyldiazoamino)-4-amino-1,2-dimethylquinazolinium chloride hydrochloride1 : (M. and B. 4986) (I). This compound, which contains the m-amidinophenyldiazoamino linkage present in the very active trypanocidal drug, isometamidium2, has babesicidal properties and is markedly active against Babesia canis in dogs.
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