Abstract
On studying the interaction of various ligands with the pharmacologically defined, recombinant human EP 2 receptor (Regan et al., Mol Pharmacol 46: 213–220, 1994), we discovered that the putative EP 1 receptor antagonist 6-isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809) also has affinity for the human EP 2 receptor. Moreover, AH 6809 behaved as an EP 2 receptor antagonist and inhibited prostaglandin E 2 (PGE 2)-stimulated increases in cyclic AMP. These findings have significant implications for studies that employ AH 6809 to determine the pharmacological basis of PGE 2-induced responses in human cells and tissues.
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