Abstract
A new rotenoid, 6-deoxyclitoriacetal, was isolated from the roots of Clitoria macrophylla and its structural assignment was established unambiguously by a series of HETCOR, COLOC and NOE difference experiments. In vitro tests showed that this compound possessed strong cytotoxic activity against cultured P-388 lymphocytic leukemia cells, but was not active with cultured KB cells. However, marginal activity was observed with vinblastine-resistant KB-V1 cells, and this was enhanced by the addition of vinblastine. This rotenoid may, therefore, interact with P-glycoprotein.
Published Version
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