Abstract
line expression of the miRNAs, the miR-30 family members and miR34a-5p were up-regulated in the CisR xenograft FFPE tissue relative to PT. Conclusion: A novel miRNA signature associated with cisplatin resistance was identified in vitro, genetic manipulation of which enhanced the cytotoxic effects of cisplatin. The 5-miR signature shows both diagnostic and prognostic biomarker potential across a number of biological mediums. Disclosure: All authors have declared no conflicts of interest.
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