Abstract
A series of 6-alkoxyisoindolin-1-ones with a magic shotgun pharmacological profile are presented as potential antipsychotics. The in vitro pharmacological profile includes D 2 partial agonism (30–55%), 5-HT 1A partial agonism (60–90%), and 5-HT 2A antagonism. Selected compounds in this series displayed good in vivo activity and potency.
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