Abstract
Sleep disturbance and fatigue are common in Crohn's disease (CD) with few effective treatment options. This study presents the first 2-phase open trial for insomnia and fatigue in young adults with CD: Phase 1) Brief behavior therapy for sleep in IBD (BBTS-I) over 4 weeks followed by Phase 2) maintenance BBTS-I alone or with bupropion (BUP) added over 8 weeks. Primary outcomes were improvement in sleep (Pittsburgh Sleep Quality Index; PSQI) and fatigue (Multidimensional Fatigue Inventory; MFI). Secondary outcomes were effects on depression (Hamilton Rating Scale; HRSD-minus sleep item), anxiety (HRSA-minus sleep item), and gastrointestinal symptoms (GIs).
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