Abstract
Those at clinical high risk for developing psychosis have attenuated psychotic symptoms as well as cognitive dysfunction, consistent with the psychosis prodrome. Brain-derived neurotrophic factor (BDNF) is a neurotrophin involved in learning and memory. The mature form (mBDNF), processed from proBDNF, has been demonstrated to be decreased in peripheral blood and post mortem cortex in schizophrenia and in peripheral blood in the psychosis prodrome. Some studies suggest a positive correlation between cognition and serum mBDNF levels in schizophrenia. To date only one small pilot study failed to demonstrate an association with cognition in CHR, thus the objective of this study is to examine serum BDNF levels and its relationship to cognition in CHR.
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