ИНТЕРЛЕЙКИН-6 – МАРКЕР СУБКЛИНИЧЕСКОГО ВОСПАЛЕНИЯ У БОЛЬНЫХ ИБС В СТАРЧЕСКОМ ВОЗРАСТЕ И ДОЛГОЖИТЕЛЕЙ

Abstract

Introduction. Interleukin-6 is a cytokine involved in the regulation of immune reactions, in the processes of hematopoiesis and inflammation. Levels of interleukin-6 in the blood correlate with the development of senile asthenia. Aim. The study aim was to determine the blood concentration of interleukin-6 and to evaluate the relationship of this cytokine with a number of pathological conditions in very old and centenarians with coronary artery disease. Material and Methods. 128 patients were enrolled in the cross-sectional study of interleukin-6 in very elderly patients and centenarians with coronary artery disease: 94 with coronary artery disease – in the study group, 34 without coronary artery disease – in the control group. The mean age of study patient was 88.3+5.3 years (76 to 98 years). Serum interleukin-6 concentrations (N<7.0 pg/ml) were determined by enzyme-linked immunosorbent assay. Results and discussion. Elevated interleukin-6 levels were found in 45.3% of patients. Mean interleukin-6 concentration was 8.2+6.3 (1.5-36.2) pg/ml. In patients with coronary artery disease mean interleukin-6 concentration reached 9.0 pg/ ml, in the control group – 5.8 pg/ml (p=0.001). Significantly higher interleukin-6 levels were found in patients with heart failure – 11.2 and 6.6 pg/ml, respectively (p=0.00005). Among patients with hyperuricemia mean interleukin-6 values reached 10.8+4.8 pg/ml. Positive correlations were found between interleukin-6 level and leukocytes count (r=0.29; p=0.002), neutrophils count (r=0.37; p=0.00002) and tumor necrosis factor-α (r=0.39; p=0.007). In patients with elevated interleukin-6 level lower Barthel index (70.7 and 80.7, respectively, р=0.003) and IADL scale (3.4 and 5.0, respectively, р=0.0002) values were observed. Conclusion. In patients with chronic coronary artery disease in very old age and centenarians an increase level of interleukin-6 is often found. Higher levels of interleukin-6 are associated primarily with heart failure and hyperuricemia.