5PSQ-154 Determination of genetic polymorphisms of the dihydropyrimidine dehydrogenase gene in real clinical practice as predictors of severe fluoropyrimidine associated toxicity

Abstract

Background and importanceFluoropyrimidines are antineoplastic drugs used for the treatment of many types of solid tumours. Approximately 80–90% administered is metabolised by the enzyme dihydropyrimidine dehydrogenase (DPYD). Partial or total...