5PSQ-055 Safety testing assessment for the adherence of dose reduction in oncology treatment following clinical guidelines recommendations in patients prior receiving Fluoropyrimidines (5-fluorouracil, capecitabine and tegafur)

Abstract

Background and ImportanceFluoropyrimidines in solid tumours are metabolised by dihydropyrimidine dehydrogenase (DPD) enzyme, encoded by DPYD gene. Up to 3-6% of the population have a DPYD variant, which, without appropriate...