Abstract

Cancer is one of the main problems in the world due to a significant increase in incidences and mortality. Data from the Global Burden of Cancer (Globocan) in 2020, shows colorectal cancer as the third most common cancer and accounts for the third-highest mortality rate. In the Asian region; Indonesia is one of the countries reported to have the lowest incidence and mortality rates compared to other countries due to limited screening and diagnostic. The course of colorectal cancer, from tumorigenesis to metastasis, is a multifactorial process, ranging from cancer stem cells, genetic mutations, and microtumor environment, to various hematological cells.

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